MYOCD, myocardin, 93649

N. diseases: 79; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.020 Biomarker disease BEFREE <b>Conclusions:</b> These data indicate that TCF21 antagonizes the MYOCD-SRF pathway through multiple mechanisms, further establishing a role for this CAD associated gene in fundamental SMC processes and indicating the importance of smooth muscle response to vascular stress and phenotypic modulation of this cell type in CAD risk. 31815603 2020
CUI: C0152021
Disease: Congenital heart disease
Congenital heart disease 		0.310 Biomarker group GENOMICS_ENGLAND Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. 31513549 2019
CUI: C0152021
Disease: Congenital heart disease
Congenital heart disease 		0.310 Biomarker group GENOMICS_ENGLAND Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. 31513549 2019
CUI: C0549253
Disease: Dilatation of the bladder
Dilatation of the bladder 		0.300 Biomarker phenotype GENOMICS_ENGLAND These results were supported by cosegregation of MYOCD variants with the phenotype in 4 unrelated families by in vitro transactivation studies in which pathogenic variants resulted in abrogated SM gene expression and by the finding of megabladder in 2 distinct mouse models with reduced Myocd activity. 31513549 2019
CUI: C0549253
Disease: Dilatation of the bladder
Dilatation of the bladder 		0.300 Biomarker phenotype GENOMICS_ENGLAND These results were supported by cosegregation of MYOCD variants with the phenotype in 4 unrelated families by in vitro transactivation studies in which pathogenic variants resulted in abrogated SM gene expression and by the finding of megabladder in 2 distinct mouse models with reduced Myocd activity. 31513549 2019
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.300 Biomarker group GENOMICS_ENGLAND Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. 31513549 2019
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.300 Biomarker group GENOMICS_ENGLAND Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. 31513549 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.040 AlteredExpression disease BEFREE Liuwei Dihuang soft capsules inhibits the phenotypic conversion of VSMC to prevent the menopausal atherosclerosis by up-regulating the expression of myocardin. 31476440 2020
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 AlteredExpression disease BEFREE Liuwei Dihuang soft capsules inhibits the phenotypic conversion of VSMC to prevent the menopausal atherosclerosis by up-regulating the expression of myocardin. 31476440 2020
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.020 Biomarker disease BEFREE In vivo tracking on longer retention of transplanted myocardin gene-modified adipose-derived stem cells to improve erectile dysfunction in diabetic rats. 31311594 2019
CUI: C1449563
Disease: Cardiomyopathy, Familial Idiopathic
Cardiomyopathy, Familial Idiopathic 		0.020 AlteredExpression disease BEFREE We observed an increase in MYOCD levels in the endomyocardial biopsies of DCM patients associated with renal failure compared to DCM alone. 30971740 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.010 AlteredExpression group BEFREE Here, we analyzed the expression levels of MYOCD in the DCM patients with and without renal diseases. 30971740 2019
CUI: C2242703
Disease: Cardio-Renal Syndrome
Cardio-Renal Syndrome 		0.010 Biomarker disease BEFREE However, expression levels of MYOCD in the cardiac tissues of the cardiorenal syndromic patients and the effect of inhibiting MYOCD in a cardiorenal syndrome model remains to be explored. 30971740 2019
CUI: C0429087
Disease: Electrocardiogram: P-R interval
Electrocardiogram: P-R interval 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. 30679814 2019
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.400 GeneticVariation disease GWASCAT Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.400 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C0235480
Disease: Paroxysmal atrial fibrillation
Paroxysmal atrial fibrillation 		0.300 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C2585653
Disease: Persistent atrial fibrillation
Persistent atrial fibrillation 		0.300 Biomarker phenotype CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C3468561
Disease: familial atrial fibrillation
familial atrial fibrillation 		0.300 Biomarker phenotype CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C0429087
Disease: Electrocardiogram: P-R interval
Electrocardiogram: P-R interval 		0.100 GeneticVariation phenotype GWASCAT PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. 30046033 2018
CUI: C0346957
Disease: Disseminated Malignant Neoplasm
Disseminated Malignant Neoplasm 		0.010 AlteredExpression phenotype BEFREE Disseminated cancer cells employ L1CAM (cell adhesion molecule L1) to spread on capillaries and activate the mechanotransduction effectors YAP (Yes-associated protein) and MRTF (myocardin-related transcription factor). 30038252 2018
CUI: C0079680
Disease: Lentivirus Infections
Lentivirus Infections 		0.010 AlteredExpression group BEFREE Hysteromyoma cells with lentivirus infection were stimulated by lipopolysaccharide (LPS), and changes in expression levels of myocardin were detected. 30024594 2018
CUI: C2747862
Disease: Hysteromyoma
Hysteromyoma 		0.010 AlteredExpression disease BEFREE Compared with normal uterine smooth muscle cells, the expression level of myocardin in hysteromyoma cells was extremely low, or even undetectable, and expression levels of smooth muscle cell differentiation markers were also minimal, and cells were in the de-differentiated state. 30024594 2018
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.400 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.400 GeneticVariation disease GWASCAT Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018